This novel mechanism provided a new strategy for regulating the ubiquitination pathway. This study establishes an efficient ...

Edited by Ana Maria Cuervo, Albert Einstein College of Medicine, Bronx, NY; received June 7, 2024; accepted February 26, 2025 ...

TLR4 endocytosis requires the TLR4 intracellular signaling domain, contributions by phospholipase C gamma 2, spleen tyrosine kinase, E1/E2 ubiquitination enzymes, but not canonical TLR signaling ...

Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University, Chongqing 400712, China National Citrus Engineering ...

CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Beijing National Laboratory for Molecular Science (BNLMS), ...

Covalent Lithium is a joint venture between subsidiaries of Sociedad Química y Minera de Chile SA (SQM) and Wesfarmers, to develop and operate the Mount Holland Lithium Project and the Kwinana Lithium ...

In the covalent ligand discovery pipeline, quantitative proteomics can be used to establish selectivity profiles and provide critical mechanistic insight into the action of lead compounds. Current ...

Modulation of T-cell activation is therefore a potential strategy to target inflammation in atherosclerosis. Ubiquitination is an important regulatory mechanism of T-cell activation and several E3 ...

Covalent conjugation of ubiquitin to proteins plays a crucial role in a wide variety of biological processes (1). Ubiquitin is a 76-aa protein that, as its name implies, is ubiquitously distributed ...