The urea cycle is the main way that the human body disposes of nitrogen waste. New research suggests that disruptions in this process may be an early sign of cancer. Share on Pinterest Blood ...

CPS1 is a gene that gives instructions on how to make the carbamoyl phosphate synthetase I enzyme. This enzyme is involved in the urea cycle, a series of metabolic processes in liver cells.

In previous research, Dr. Ayelet Erez of Weizmann's Biological Regulation Department showed that one of the enzymes in the urea cycle has been inactivated within many cancerous tumors, increasing ...

Suppressing urea cycle enzymes, particularly ODC1, using short hairpin RNAs halved the amount of putrescine and brought GABA back to levels seen in control astrocytes. In addition, inhibiting ODC1 ...

In previous research, Dr. Ayelet Erez of Weizmann's Biological Regulation Department showed that one of the enzymes in the urea cycle has been inactivated within many cancerous tumors, increasing ...

The urea cycle is made up of six enzymes that rid the body of nitrogen produced during the metabolism of amino acids in food. They convert it to urea, which is eliminated in urine.

New results reveal the urea cycle in astrocytes as the link between amyloid-beta accumulation and memory loss, providing enzyme ODC1 as a new therapeutic target to treat Alzheimer’s disease Peer ...

CAMBRIDGE, Mass., March 21, 2024 (GLOBE NEWSWIRE) -- CAMP4 Therapeutics Corp., a clinical-stage biotechnology company harnessing the power of regulatory RNA to restore healthy gene expression ...

Differentiation of transient hyperammonemia of the newborn and urea cycle enzyme defects by clinical presentation. J Pediatr 107:712-719, 1985. Simplified schematic of urea cycle with enzyme defects.

Urea cycle disorders As the name implies, these conditions describe a problem with one of the enzymes or transporter molecules in the urea cycle . The urea cycle is the waste-removal process where ...

"Pharmacological approaches to restore the expression of urea cycle enzymes would greatly expand treatment options for ccRCC patients, whose current therapies only benefit a small subset," Simon said.

Urea cycle disorders are a group of inherited metabolic disorders that make it difficult for patients to remove toxic waste products. The Food and Drug Administration (FDA) has granted Orphan Drug ...