Its flagship academic medical centers in Boston, Massachusetts General Hospital and Brigham and Women’s Hospital, anchor a health care hub that is arguably the best in the country, if not the world. Reimbursement rates from insurers are growing more slowly than expenses.

BOSTON - Mass General Brigham, the largest health care system in Massachusetts, announced layoffs Monday that will affect hundreds of workers, citing a $250 million projected budget gap. The layoffs will be "focused on non-clinical and non-patient facing roles,

Mass General Brigham attributed the layoffs to an expected budget shortfall of $250 billion over the next two years.

Facing rising costs and hoping to make its sprawling network more efficient, the state’s largest private employer aims to cut payroll costs by over $200 million.

The layoffs could potentially impact employees at 12 hospitals under the MGB umbrella: While executives say the sweeping cuts are aimed at management and administrative-level employees with no impact on front-line workers, Boston University School of Public Health’s David Rosenbloom suspects the changes could reach patients.

Wentworth-Douglass Hospital was not spared from layoffs by Mass General Brigham as it cited an anticipated "budget gap" of $250 million.

At least three high-level employees at Nantucket Cottage Hospital left abruptly recently, after the parent company of the island's only hospital announced layoffs last week.

Nonprofit giant Mass General Brigham (MGB) will be laying off numerous non-clinical employees to close major budget shortfalls. | The major nonprofit system declined to put a number on the cuts and consolidations,

Mass General Brigham announced layoffs for hundreds of administrative and management employees on Monday in anticipation of a $250 million budget gap, an unprecedented decision for Massachusetts’ largest private employer.

Mass General Brigham announces layoffs to address a $250 million budget deficit, focusing on non-clinical roles, aiming for efficiency and a resilient future.