CHICAGO — A single infusion of zimislecel, an investigational stem cell-based therapy, restored physiologic islet function and conferred improved outcomes and insulin independence at 1 year ...

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of ...

Interestingly, upon closer inspection, goblet cell mucin-containing secretory vesicles were also further away from the epithelial surface, and there were fewer vesicles undergoing expulsion in the STZ ...

Learn about white blood cells, which help your body fight inflammation and infections. A high or low white blood cell count may be associated with certain health conditions.

This relationship is mutually supportive: beneficial gut bacteria promote healthy goblet cell function, while goblet cells produce the necessary environment for a balanced microbiome.

This relationship is mutually supportive: beneficial gut bacteria promote healthy goblet cell function, while goblet cells produce the necessary environment for a balanced microbiome.

The goblet cells fill their secretory vesicles with Muc2 while migrating from the crypt bottom 5 and contain other mucus components, such as the Fc fragment of IgG-binding protein, chloride channel ...

Submucosal glands and cells called goblet cells pump out gobbets of mucin proteins.

The mucin2 (MUC2) mucus barrier acts as the first barrier that prevents direct contact between intestinal bacteria and colonic epithelial cells. Bacterial factors related to the MUC2 mucus barrier ...

Rab7-mediated changes in goblet cell function play a crucial role in triggering gut inflammation during colitis.

These two new studies highlight a specialized function for IRE1β in mucin goblet cells and provide an additional example of convergent evolution in the mechanisms by which ER stress sensors detect ...

The major components of mucus secreted by goblet cells are MUC2 mucin and the mucus-associated protein, FCGBP (IgGFc-binding protein). In this study, we determine if FCGBP and MUC2 mucin were ...