Drug Combination PK - Search

About 183,000 results

Open links in new tab

nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Design of Phase I Combination Trials: Recommendations of the …
The design and conduct of the phase 1 combination trial present specific challenges, such as the optimum selection of agents to combine among the range of possible combinations; the selection of the appropriate dose and schedule (including which drug or drugs to dose escalate); drug …
- Co-chairs: Mark J. Ratain, Michael LeBlanc
- Non-voting members: Rajeev Agarwal, Lori Minasian, Peter Ujhazy
- NCI liaison: S. Percy Ivy
- Past chair and co-chair: Lesley Seymour, Donald Berry
- Pharmacokinetics and drug-i…
  Drugs used in cancer treatment exhibit varied temporal dynamics of absorption …
- Recent Pharmacokinetic Stud…
  A combination of pharmacokinetics/pharmacodynamics …
- A Novel Integrated Pharmac…
  Herein, we report a novel generic PK-PD model for combination therapy by …
- A Novel Integrated Pharmac…
  Herein, we report a novel generic PK-PD model for combination therapy by …
- Anti-cancer drug combinatio…
  Pharmacokinetic (PK) assessments play a key role throughout the clinical …
See results only from pmc.ncbi.nlm.nih.gov
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Pharmacokinetics and drug-interactions determine …
Drugs used in cancer treatment exhibit varied temporal dynamics of absorption and clearance, summarized by their pharmacokinetic (PK) parameters. Typically these dynamics are neglected in evolutionary models of cancer progression …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Recent Pharmacokinetic Studies in Combination Therapies for …
A combination of pharmacokinetics/pharmacodynamics (PK/PD) and population pharmacokinetics (PopPK) and the development of PK/PD models in PK studies were good ways to determine …
Videos of Drug Combination PK

bing.com › videos
Watch video
6:26
Overview of PK-PD relationship / Drug Dynamic
12.8K viewsNov 8, 2021
YouTubePharmacy Ed
Watch video
4:21
PK parameters for absorption, distribution, metabolism, & excretion
11.7K viewsAug 23, 2019
YouTubeChem Help ASAP
Watch video
2:47
Bringing Medicines to the Body: PK/PD & Clinical Pharmacology
23.1K viewsJan 9, 2014
YouTubeGenentech
Watch video
4:05
Introduction to PK - BioAvailability & BioEquivalence
8.9K viewsAug 2, 2019
YouTubepharmacology tutorials
ATS Journals
https://www.atsjournals.org › doi › full
Pharmacologic Principles for Combination Therapy | Proceedings …
Apr 14, 2005 · Pharmacokinetics and drug-induced adaptive changes in receptors and cell signaling pathways are summarized, emphasizing their importance for potential combination …
- Author: Myron L. Toews, David B. Bylund
- Publish Year: 2005
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to …
Herein, we report a novel generic PK-PD model for combination therapy by considering apparent contributions from individual drugs coadministered. Doxorubicin (Dox) and sorafenib (Sor) …
ScienceDirect
https://www.sciencedirect.com › science › article › pii
A graph model of combination therapies - ScienceDirect
May 1, 2022 · Successful combination therapies are determined by drug-drug interactions (DDIs). We propose a graph theory to characterize how drugs work together in a network. It combines …
People also ask
Is there a generic PK-PD model for combination therapy?
Herein, we report a novel generic PK-PD model for combination therapy by considering apparent contributions from individual drugs coadministered. Doxorubicin (Dox) and sorafenib (Sor) were used as model drugs whose PK data were obtained in mice and fit to two-compartment model.
A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evalu…
pubmed.ncbi.nlm.nih.gov
Can PKPD index be used for antibiotic combination therapy?
Deriving suitable dosing regimens for antibiotic combination therapy poses several challenges as the drug interaction can be highly complex, the traditional pharmacokinetic–pharmacodynamic (PKPD) index methodology cannot be applied straightforwardly, and exploring all possible dose combinations is unfeasible.
Semi-mechanistic pharmacokinetic–pharmacodynamic modelling of
sciencedirect.com
Can pharmacokinetic and semi-mechanistic PKPD models be combined?
A schematic overview on how pharmacokinetic (PK) models and semi-mechanistic pharmacokinetic–pharmacodynamic (PKPD) models for two antibiotics can be joined to evaluate the combined effects of dosing regimens or to design a study.
Semi-mechanistic pharmacokinetic–pharmacodynamic modelling of
sciencedirect.com
What is PK-pharmacodynamic model?
SIGNIFICANCE STATEMENT: A novel pharmacokinetic (PK)-pharmacodynamic (PD) model was developed for the assessment of combination treatment by considering contributions from individual drugs, and combination index method was incorporated to critically define in vivo synergism.
A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evalu…
pubmed.ncbi.nlm.nih.gov
What is the difference between PK-PD and interaction factor pharmacologic synergism?
Existing PK-PD models for combination therapy lack consideration of quantitative contributions from individual drugs, whereas interaction factor is always assigned arbitrarily to one drug and overstretched for the determination of in vivo pharmacologic synergism.
A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evalu…
pubmed.ncbi.nlm.nih.gov
Is PK-PD a synergy model?
In addition, this new PK-PD model was able to identify optimal dosage combination (e.g., doubling experimental Sor dose and reducing Dox dose by 50%) toward much greater degree of tumor-growth inhibition (>90%), which was consistent with stronger synergy (combination index = 0.298).
A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evalu…
pubmed.ncbi.nlm.nih.gov
Feedback
Springer
https://link.springer.com › article
Anti-cancer drug combinations approved by US FDA from 2011
Aug 27, 2022 · This review identifies 81 new drug combinations approved by the United States Food and Drug Administration (FDA) for hemato-oncology during the 2011–2021 period and …
PubMed
https://pubmed.ncbi.nlm.nih.gov
A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to …
Herein, we report a novel generic PK-PD model for combination therapy by considering apparent contributions from individual drugs coadministered. Doxorubicin (Dox) and sorafenib (Sor) …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Anti-cancer drug combinations approved by US FDA from 2011 to …
Pharmacokinetic (PK) assessments play a key role throughout the clinical development of drug combinations, informing potential PK interactions. But most importantly, they allow the …
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Semi-mechanistic pharmacokinetic–pharmacodynamic modelling …
Jul 1, 2018 · To outline how the interaction between two antibiotics has been characterized in semi-mechanistic PKPD models. We also explain how such models can be applied to support …

Some results have been removed
Pagination
- 1
- 2
- 3
- 4
- Next